I have used this site for years and never had a problem with malware. It is not one of the most extensive lists of freeware out there, but it also does NOT try to scam you by slipping in shareware and $ware programs like some other supposed freeware sites do.
Not all the downloads on this site are bad/infected/corrupt - but some of them are. Use this site at your own risk. Instead, I suggest www.cnet.com, or ***** - both of which are safe and time tested.
Many people here are referencing a MalwareDomains blacklist. This is outdated information (from 2009!) due to the fact that one of their servers was temporarily hijacked.
Source: http://freewarehome.com/index.html?http%3A//freewarehome.com/bx/index.php%3Faction%3Dvthread%26forum%3D15%26topic%3D11117
I have downloaded and used many programs from this site. None of the programs contained viruses, spyware, or adware. I highly recommend this site to people who are looking for free software.